I got the impression from several things I've read that none of the original MIF-IPC cards, especially the MIF-IPC-A would not work correctly in anything but the original XT and PCs so it wouldn't work with my 486. If I'm wrong someone let me know ASAP so I can bid on that sucker!

I've yet to see a definitive answer. Here's a little more descriptive post:
If you have the original MPU401, like I did, then apparently you need
to send it in to Roland to get it to work on an AT-bus. They add a chip and
lotsa wires. They do the job for free, at least they did at the time I sent
mine in. This issue is apart from the IRQ2 issue. If you have the more recent
MPU401 (the Roland single card, no outboard box version), then this mod is not
necessary.
Too many questions to draw any sort of conclusion though...
Is his "original MPU401" the 1984-released "DG" version?
Were the "chip and lotsa wires" added to the MIF card, or to the MPU?
Not to mention the incorrect statement that the "more recent MPU401" (the MPU-IPC(-T)) does not have external connector box...
In any case, I have a Voyetra V-4001 with CB-4001 connector box that I don't foresee using anytime soon. It's 100% MPU-401 compatible (contains the actual Roland chipset), and can be yours for the low, low cost of shipping reimbursement (~$4.00). I can post a photo later, if you want to see what it looks like.