No, it's not possible.
At a minimum, it seems like basic Eye and Walk icons might be possible, even without the pathfinding ability, since these actions are already present with the mouse support in most (all?) SCI0 games.
Speaking of "looking" with the mouse, for the most part, you get the same messages as if you'd used the parser. The two parser-driven Quest for Glory games seem to be exceptions though. Whereas QfG1 cycles through a number of cute messages when you look at inconsequential things, QfG2 seems to contain a fair amount of dialogue that can only be seen by using the mouse (AFAIK).